PDCD6IP

Across TCGA pan-cancer cohorts, PDCD6IP RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PDCD6IP’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PDCD6IP RNA is repressed in tumor relative to normal tissue. In most cancer types PDCD6IP is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, LIHC, and COAD are the cancer types where PDCD6IP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDCD6IP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.697	<.001	11	view →
LIHC	All	II,III,IV	+0.764	<.001	9	view →
COAD	Female	All	−1.057	<.001	8	view →
BLCA	Male	All	+0.471	.001	8	view →
LUSC	Female	II,III,IV	−0.901	<.001	7	view →
THCA	All	All	−0.248	.005	6	view →
LUAD	Female	All	−0.390	<.001	5	view →
CHOL	All	All	+1.007	<.001	2	view →
UCEC	All	All	−0.551	.002	2	view →
PRAD	All	All	+0.248	.022	2	view →
READ	All	All	−0.649	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PDCD6IP–KIRC

Open the KIRC breakdown →