PDCD6

Across TCGA cell cohorts, PDCD6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,260 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible PDCD6-associated GO terms across cancer lineages are Meiotic recombination checkpoint signaling, L-methionine metabolic process, and Gamma-tubulin complex localization. Each is linked with PDCD6 in more than 10 cancer types. Because this analysis shows association rather than direction, both PDCD6-to-partner and partner-to-PDCD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Meiotic recombination checkpoint signaling grouped by PDCD6-low versus PDCD6-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD6→partner) and Y-score (partner→PDCD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Meiotic recombination checkpoint signaling →	+0.248	+0.917	<.001	<.001	3	11
SKIN	L-methionine metabolic process →	+0.062	+0.327	<.001	.009	3	11
LUNG_SCLC	Gamma-tubulin complex localization →	+0.185	+0.784	<.001	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Tricarboxylic acid cycle →	+0.133	+0.916	<.001	<.001	3	8
LUNG_SCLC	Response to stilbenoid →	+0.227	+0.722	.001	.003	2	9
SKIN	Replication-born double-strand break repair via sister chromatid exchange →	+0.134	+0.543	.002	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,260 associations by consensus.

Meiotic recombination checkpoint signaling by PDCD6 expression — BREAST

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