PDCD6

Across TCGA pan-cancer cohorts, PDCD6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PDCD6 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher PDCD6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PDCD6 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SCLC show a favorable association.

UVM, KICH, and LIHC are the cancer types where PDCD6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.328	0.750	<.001	124	view →
KICH	DFS	Tertile	II,III,IV	0.373	0.950	<.001	87	view →
LIHC	DFS	Median	All	0.435	0.643	<.001	76	view →
KIRP	DFS	Median	II,III,IV	0.286	0.692	.001	46	view →
CESC	DFS	Quartile	All	0.693	0.871	.003	36	view →
BLCA	OS	Quartile	All	0.600	0.359	.011	34	view →
COAD	DFS	Median	III,IV	0.225	0.576	.003	22	view →
READ	OS	Median	All	0.719	0.900	.005	19	view →
PRAD	DFS	Tertile	All	0.699	0.844	.022	10	view →
CHOL	DFS	Tertile	III,IV	0.162	0.779	.024	9	view →
SARC	OS	Median	All	0.686	0.838	.010	8	view →
BRCA	DFS	Tertile	All	0.879	0.926	.012	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PDCD6–UVM (DFS)

Open the UVM breakdown →