PDCD4

Across TCGA patient cohorts, PDCD4 mutation is significantly associated with the RNA expression of many other genes, with 1,514 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD4-associated genes across cancer lineages are UQCRH, MRPL22, and ATXN7L3P1. Each is linked with PDCD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD4-to-partner and partner-to-PDCD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by PDCD4-low versus PDCD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD4→partner) and Y-score (partner→PDCD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRH →	+0.801	+3.732	.009	<.001	3	2
UCEC	MRPL22 →	+0.485	+3.753	<.001	<.001	3	2
COAD	ATXN7L3P1 →	+0.115	+3.869	<.001	<.001	3	2
COAD	FAM204BP →	+0.313	+3.420	.002	.007	3	2
COAD	RN7SL340P →	+0.150	+4.332	<.001	.006	3	2
UCEC	RNA5SP146 →	+0.451	+2.940	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,514 associations by consensus.

UQCRH by PDCD4 expression — UCEC

Explore this box plot interactively →