PDCD2L

Across TCGA patient cohorts, PDCD2L mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDCD2L-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and Notch1. Each is linked with PDCD2L in more than 1 cancer types. Because this analysis shows association rather than direction, both PDCD2L-to-partner and partner-to-PDCD2L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by PDCD2L-low versus PDCD2L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDCD2L→partner) and Y-score (partner→PDCD2L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.292	+3.459	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.178	-2.321	.003	.035	3	1
UCEC	Notch1 →	+0.262	+3.335	<.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.123	-2.321	.017	.035	3	1
UCEC	Stathmin →	+0.143	+2.321	.038	.035	3	1
UCEC	Syk →	+0.378	+2.335	.045	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by PDCD2L expression — UCEC

Explore this box plot interactively →