PCYT1A

Across TCGA patient cohorts, PCYT1A mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCYT1A-associated genes across cancer lineages are EGFR_pY1068, STAT3_pY705, and Bak. Each is linked with PCYT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYT1A-to-partner and partner-to-PCYT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by PCYT1A-low versus PCYT1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT1A→partner) and Y-score (partner→PCYT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.249	-3.169	.033	.019	3	1
UCEC	STAT3_pY705 →	-0.410	-3.449	<.001	.005	3	1
UCEC	Bak →	+0.260	+3.169	.026	.018	3	1
UCEC	Caspase-7-cleavedD198 →	+0.760	+3.479	.005	.002	3	1
UCEC	ERK2 →	+0.191	+2.584	.034	.011	2	1
UCEC	c-Kit →	-0.216	-2.584	.047	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

EGFR_pY1068 by PCYT1A expression — UCEC

Explore this box plot interactively →