PCYOX1L

Across TCGA patient cohorts, PCYOX1L mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCYOX1L-associated genes across cancer lineages are JNK_pT183_Y185, 14-3-3_beta, and EGFR_pY1068. Each is linked with PCYOX1L in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYOX1L-to-partner and partner-to-PCYOX1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by PCYOX1L-low versus PCYOX1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYOX1L→partner) and Y-score (partner→PCYOX1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.218	-2.308	.001	.006	3	2
UCEC	14-3-3_beta →	-0.115	-3.143	.005	.018	3	1
UCEC	EGFR_pY1068 →	-0.275	-2.321	.007	.006	3	1
UCEC	JNK2 →	+0.169	+1.807	.039	.027	3	1
UCEC	Ku80 →	+0.292	+3.013	.002	<.001	3	1
UCEC	p62 Lck ligand →	+0.306	+3.169	.022	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK_pT183_Y185 by PCYOX1L expression — UCEC

Explore this box plot interactively →