PCYOX1L

Across TCGA pan-cancer cohorts, PCYOX1L RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PCYOX1L data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PCYOX1L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCYOX1L expression acts as an unfavorable survival marker, although some lineages such as LUSC and PAAD show a favorable association.

KIRC, THCA, and LUSC are the cancer types where PCYOX1L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	II,III,IV	0.413	0.653	<.001	95	view →
THCA	OS	Median	II,III,IV	0.791	0.953	.006	56	view →
LUSC	OS	Median	All	0.731	0.615	.002	44	view →
MESO	OS	Median	All	0.466	0.622	.008	39	view →
PAAD	DFS	Quartile	All	0.509	0.199	.004	29	view →
LIHC	OS	Tertile	III,IV	0.402	0.744	.004	29	view →
ACC	DFS	Tertile	All	0.261	0.719	<.001	26	view →
BRCA	OS	Median	IV	0.793	0.350	.003	24	view →
STAD	DFS	Median	IV	0.123	0.668	.002	22	view →
SKCM	OS	Tertile	All	0.396	0.255	.003	14	view →
LAML	DFS	Quartile	All	0.196	0.639	.007	12	view →
SCLC	DFS	Tertile	All	0.310	0.552	.023	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PCYOX1L–KIRC (DFS)

Open the KIRC breakdown →