PCSK9

Across TCGA pan-cancer cohorts, PCSK9 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PCSK9 data layer compared with 22 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PCSK9 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCSK9 expression acts as an unfavorable survival marker.

COAD, LIHC, and PRAD are the cancer types where PCSK9 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.371	0.695	.002	12	view →
LIHC	OS	Median	All	0.105	0.774	.002	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

PCSK9–COAD (DFS)

Open the COAD breakdown →