PCSK9

Across TCGA pan-cancer cohorts, PCSK9 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PCSK9’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PCSK9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCSK9 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where PCSK9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCSK9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	+4.644	<.001	11	view →
HNSC	Male	III,IV	+2.903	<.001	11	view →
KIRC	All	II,III,IV	−0.366	<.001	11	view →
LUAD	Male	III,IV	−2.921	<.001	9	view →
STAD	All	All	+1.502	<.001	9	view →
KIRP	Male	All	−0.337	<.001	7	view →
UCEC	All	All	+1.543	<.001	6	view →
BLCA	All	III,IV	+1.489	.010	6	view →
BRCA	Female	All	+0.329	<.001	6	view →
THCA	All	All	+0.088	<.001	5	view →
LIHC	Male	All	+1.027	<.001	4	view →
ESCA	All	All	+2.900	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PCSK9–COAD

Open the COAD breakdown →