PCSK9

Across TCGA patient cohorts, PCSK9 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,315 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PCSK9-associated proteins across cancer lineages are FASN, HMGCS1, and PRRC2B. Each is linked with PCSK9 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCSK9-to-partner and partner-to-PCSK9 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK9 versus FASN in UCEC, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK9→partner) and Y-score (partner→PCSK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.452	+1.440	<.001	<.001	3	4
HNSC	HMGCS1 →	+0.743	+1.627	<.001	<.001	3	4
COAD	PRRC2B →	+0.203	+0.709	.006	.009	3	4
HNSC	MCM2 →	+0.548	+1.379	<.001	<.001	3	4
HNSC	MCM4 →	+0.564	+1.459	<.001	<.001	3	4
HNSC	MCM6 →	+0.457	+1.296	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,315 associations by consensus.

PCSK9 vs FASN — UCEC

Explore this scatter interactively →