PCSK9

Across TCGA patient cohorts, PCSK9 mutation is significantly associated with the RNA expression of many other genes, with 1,240 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK9-associated genes across cancer lineages are HMGB1P35, MIR4500, and MTND5P13. Each is linked with PCSK9 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK9-to-partner and partner-to-PCSK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMGB1P35 grouped by PCSK9-low versus PCSK9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK9→partner) and Y-score (partner→PCSK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	HMGB1P35 →	+0.065	+1.784	.001	.005	3	3
LIHC	MIR4500 →	+0.509	+4.647	<.001	.007	3	2
LUAD	MTND5P13 →	+0.090	+5.712	<.001	.003	3	2
COAD	RNA5SP281 →	+0.279	+5.831	<.001	<.001	3	2
COAD	FAM230F →	+0.053	+4.399	<.001	.006	3	2
SKCM	RFPL4AP5 →	+0.011	+3.980	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,240 associations by consensus.

HMGB1P35 by PCSK9 expression — SKCM

Explore this box plot interactively →