PCSK9

Across TCGA patient cohorts, PCSK9 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK9-associated genes across cancer lineages are MEK1, Notch1, and Caspase-8. Each is linked with PCSK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK9-to-partner and partner-to-PCSK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by PCSK9-low versus PCSK9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK9→partner) and Y-score (partner→PCSK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.418	+2.584	.004	.010	3	2
SKCM	Notch1 →	+0.202	+1.749	.008	.049	3	2
UCEC	Caspase-8 →	-0.221	-3.558	.028	.002	3	2
SKCM	IRS1 →	+0.239	+3.339	<.001	.004	3	2
UCEC	14-3-3_beta →	-0.095	-2.295	.018	.033	3	1
UCEC	eIF4G →	+0.364	+2.584	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MEK1 by PCSK9 expression — UCEC

Explore this box plot interactively →