PCSK9

Across TCGA cell cohorts, PCSK9 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,722 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PCSK9-associated GO terms across cancer lineages are Cholesterol biosynthetic process via desmosterol, Cholesterol biosynthetic process via lathosterol, and Central nervous system morphogenesis. Each is linked with PCSK9 in more than 7 cancer types. Because this analysis shows association rather than direction, both PCSK9-to-partner and partner-to-PCSK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cholesterol biosynthetic process via desmosterol grouped by PCSK9-low versus PCSK9-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK9→partner) and Y-score (partner→PCSK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cholesterol biosynthetic process via desmosterol →	+0.210	+3.086	<.001	<.001	3	8
BONE	Cholesterol biosynthetic process via lathosterol →	+0.230	+3.172	<.001	<.001	3	8
KIDNEY	Central nervous system morphogenesis →	+0.170	+0.841	.003	.008	2	8
STOMACH	Intracellular potassium ion homeostasis →	+0.158	+2.483	.003	.001	3	7
BONE	Secondary alcohol biosynthetic process →	+0.194	+3.035	<.001	<.001	3	7
LARGE_INTESTINE	SREBP signaling pathway →	+0.139	+2.681	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,722 associations by consensus.

Cholesterol biosynthetic process via desmosterol by PCSK9 expression — BONE

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