PCSK9

Across TCGA cell cohorts, PCSK9 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCSK9-associated genes across cancer lineages are TFDP3, TAFA1, and PNMA3. Each is linked with PCSK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK9-to-partner and partner-to-PCSK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFDP3 grouped by PCSK9-low versus PCSK9-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK9→partner) and Y-score (partner→PCSK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TFDP3 →	+0.024	+2.933	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	PNMA3 →	+0.193	+3.044	<.001	.002	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1
LARGE_INTESTINE	KRTAP10-12 →	+0.053	+3.247	<.001	.001	3	1
LARGE_INTESTINE	BPIFA1 →	+0.152	+2.688	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

TFDP3 by PCSK9 expression — LARGE_INTESTINE

Explore this box plot interactively →