PCSK6

Across TCGA patient cohorts, PCSK6 mutation is significantly associated with the RNA expression of many other genes, with 3,130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCSK6-associated genes across cancer lineages are RN7SL602P, SVIP, and SNX3P1X. Each is linked with PCSK6 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK6-to-partner and partner-to-PCSK6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL602P grouped by PCSK6-low versus PCSK6-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK6→partner) and Y-score (partner→PCSK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL602P →	+0.132	+3.791	<.001	.004	3	3
UCEC	SVIP →	+0.397	+2.191	.002	.001	3	3
GBM	SNX3P1X →	+0.380	+6.189	<.001	.001	3	2
SKCM	RN7SL754P →	+0.095	+1.783	.002	.008	3	2
UCEC	BTBD10 →	+0.399	+2.354	<.001	<.001	3	2
UCEC	TMEM138 →	+0.194	+1.642	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,130 associations by consensus.

RN7SL602P by PCSK6 expression — LUAD

Explore this box plot interactively →