PCSK6-AS1

Across TCGA pan-cancer cohorts, PCSK6-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PCSK6-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PCSK6-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PCSK6-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and CESC show a favorable association.

ACC, KIRP, and THCA are the cancer types where PCSK6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.109	0.547	<.001	93	view →
KIRP	OS	Tertile	II,III,IV	0.120	0.576	<.001	90	view →
THCA	DFS	Tertile	II,III,IV	0.302	0.742	<.001	81	view →
BLCA	OS	Tertile	All	0.927	0.622	.001	72	view →
KIRC	DFS	Quartile	All	0.503	0.706	.001	60	view →
CESC	OS	Tertile	II,III,IV	0.892	0.694	.016	54	view →
SKCM	DFS	Tertile	All	0.566	0.777	.002	27	view →
BRCA	DFS	Quartile	III,IV	0.898	0.753	.013	25	view →
DLBC	DFS	Tertile	III,IV	0.070	0.855	.008	24	view →
ESCA	OS	Median	II,III,IV	0.464	1.000	.006	22	view →
LGG	DFS	Tertile	All	0.939	0.796	.001	21	view →
HNSC	OS	Tertile	All	0.692	0.768	.021	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PCSK6-AS1–ACC (DFS)

Open the ACC breakdown →