PCSK6-AS1

Across TCGA pan-cancer cohorts, PCSK6-AS1 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of PCSK6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PCSK6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCSK6-AS1 is over-expressed in tumor.

KIRC, COAD, and BRCA are the cancer types where PCSK6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCSK6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	IV	+0.188	<.001	11	view →
COAD	All	All	+0.160	.001	5	view →
BRCA	All	All	+0.171	.008	4	view →
STAD	All	All	+0.135	.002	4	view →
HNSC	Male	II,III,IV	+0.041	.042	4	view →
LUSC	Male	All	+0.172	.040	2	view →
READ	All	All	+0.163	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

PCSK6-AS1–KIRC

Open the KIRC breakdown →