PCSK4

Across TCGA cell cohorts, PCSK4 mutation is significantly associated with the RNA expression of many other genes, with 398 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCSK4-associated genes across cancer lineages are BTNL3, OR1L6, and KRT76. Each is linked with PCSK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK4-to-partner and partner-to-PCSK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BTNL3 grouped by PCSK4-low versus PCSK4-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK4→partner) and Y-score (partner→PCSK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	BTNL3 →	+0.005	+4.169	<.001	.008	3	1
BONE	OR1L6 →	+0.015	+4.169	<.001	.008	3	1
BONE	KRT76 →	+0.209	+4.000	.001	.008	3	1
BONE	C2orf80 →	+0.095	+4.169	<.001	.008	3	1
BONE	POTEB →	+0.010	+4.169	<.001	.008	3	1
BONE	OR7E24 →	+0.012	+5.129	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 398 associations by consensus.

BTNL3 by PCSK4 expression — BONE

Explore this box plot interactively →