PCSK1N

Across TCGA patient cohorts, PCSK1N mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. COAD shows the largest number of these associations.

The most reproducible PCSK1N-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ naive T-cells. Each is linked with PCSK1N in more than 1 cancer types. Because this analysis shows association rather than direction, both PCSK1N-to-partner and partner-to-PCSK1N results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by PCSK1N-low versus PCSK1N-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK1N→partner) and Y-score (partner→PCSK1N) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.089	+6.142	<.001	.027	3	1
COAD	CD8+ Tcm →	+0.151	+5.917	<.001	.032	3	1
COAD	CD4+ naive T-cells →	+0.047	+6.142	<.001	.027	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CD8+ T-cells by PCSK1N expression — COAD

Explore this box plot interactively →