PCSK1

Across TCGA patient cohorts, PCSK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 9,335 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCSK1-associated proteins across cancer lineages are NNMT, ARHGAP39_S366, and SNX2_S185. Each is linked with PCSK1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCSK1-to-partner and partner-to-PCSK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK1 versus NNMT in UCEC, with a Pearson correlation of 0.42.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK1→partner) and Y-score (partner→PCSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NNMT →	+0.810	+1.016	<.001	.005	3	4
UCEC	ARHGAP39_S366 →	-0.711	-1.389	<.001	.002	3	3
COAD	SNX2_S185 →	+0.692	+2.910	.002	.005	3	3
BRCA	DCLK1 →	+0.703	+1.692	<.001	.004	3	3
BRCA	FAM114A2 →	+0.220	+1.482	.004	.003	3	3
BRCA	GPRIN3_S32 →	+0.588	+1.061	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,335 associations by consensus.

PCSK1 vs NNMT — UCEC

Explore this scatter interactively →