PCSK1

Across TCGA patient cohorts, PCSK1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,883 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible PCSK1-associated genes across cancer lineages are CHGA, SYP, and RUNDC3A. Each is linked with PCSK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCSK1-to-partner and partner-to-PCSK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCSK1 versus CHGA in PDAC, with a Pearson correlation of 0.75.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK1→partner) and Y-score (partner→PCSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CHGA →	+2.109	+0.830	<.001	<.001	3	3
GBM	SYP →	+1.290	+0.698	<.001	<.001	3	3
GBM	RUNDC3A →	+0.829	+0.451	<.001	.002	3	3
LUAD	TSPAN11 →	+1.355	+1.280	.005	.006	3	3
GBM	PEX5L →	+1.181	+0.605	<.001	<.001	3	3
GBM	SLC8A2 →	+1.025	+0.547	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,883 associations by consensus.

PCSK1 vs CHGA — PDAC

Explore this scatter interactively →