PCSK1

Across TCGA cell cohorts, PCSK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,163 significant associations in total. CNS shows the largest number of these associations.

The most reproducible PCSK1-associated GO terms across cancer lineages are Negative regulation of syncytium formation by plasma membrane fusion, Regulation of myoblast fusion, and Protein localization to nucleus. Each is linked with PCSK1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PCSK1-to-partner and partner-to-PCSK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of syncytium formation by plasma membrane fusion grouped by PCSK1-low versus PCSK1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCSK1→partner) and Y-score (partner→PCSK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of syncytium formation by plasma membrane fusion →	+0.103	+3.723	<.001	<.001	3	9
LUNG_SCLC	Regulation of myoblast fusion →	+0.103	+4.434	<.001	<.001	3	8
BLOOD_Myeloma	Protein localization to nucleus →	+0.071	+0.077	<.001	.006	3	8
LUNG_SCLC	Negative regulation of myoblast fusion →	+0.102	+3.154	<.001	.002	3	8
BLOOD_Myeloma	Proton motive force-driven mitochondrial ATP synthesis →	+0.064	+0.052	.004	.002	3	8
CNS	Positive regulation of cytoplasmic translation →	+0.063	+0.932	<.001	.002	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,163 associations by consensus.

Negative regulation of syncytium formation by plasma membrane fusion by PCSK1 expression — LUNG_SCLC

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