PCOLCE

Across TCGA pan-cancer cohorts, PCOLCE mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PCOLCE’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where PCOLCE mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PCOLCE is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

PDAC, HNSC, and LSCC are the cancer types where PCOLCE tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCOLCE mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+0.950	<.001	6	view →
HNSC	All	All	−0.355	.001	6	view →
LSCC	Male	All	+0.208	.009	3	view →
CCRCC	Male	III,IV	−0.350	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

PCOLCE–PDAC

Open the PDAC breakdown →