PCNPP4

Across TCGA pan-cancer cohorts, PCNPP4 RNA is linked to patient survival in 10 of 34 cancer types, making it the most broadly survival-associated PCNPP4 data layer.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher PCNPP4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PCNPP4 expression acts as an unfavorable survival marker, although some lineages such as LGG and ACC show a favorable association.

LUSC, KIRC, and PAAD are the cancer types where PCNPP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Tertile	III,IV	0.197	0.603	<.001	69	view →
KIRC	DFS	Tertile	All	0.224	0.648	<.001	24	view →
PAAD	DFS	Tertile	II,III,IV	0.101	0.474	<.001	18	view →
STAD	OS	Tertile	IV	0.138	0.585	.010	18	view →
THYM	DFS	Tertile	II,III,IV	0.621	0.933	.009	18	view →
GBM	OS	Tertile	All	0.319	0.438	.028	15	view →
SARC	OS	Tertile	All	0.258	0.771	.013	9	view →
BRCA	DFS	Tertile	II,III,IV	0.875	0.945	.027	6	view →
LGG	OS	Tertile	All	0.665	0.424	.046	3	view →
ACC	DFS	Tertile	All	1.000	0.366	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

PCNPP4–LUSC (OS)

Open the LUSC breakdown →