PCNP

Across TCGA patient cohorts, PCNP mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNP-associated genes across cancer lineages are HER3_pY1289, Ku80, and MAPK_pT202_Y204. Each is linked with PCNP in more than 1 cancer types. Because this analysis shows association rather than direction, both PCNP-to-partner and partner-to-PCNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HER3_pY1289 grouped by PCNP-low versus PCNP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNP→partner) and Y-score (partner→PCNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HER3_pY1289 →	+0.077	+1.611	.041	.043	3	1
UCEC	Ku80 →	+0.254	+2.128	.014	.010	3	1
UCEC	MAPK_pT202_Y204 →	-0.441	-2.321	.031	.034	3	1
UCEC	MEK1 →	+0.502	+2.807	.001	.003	3	1
UCEC	p70-S6K_pT389 →	-0.205	-2.999	.013	.035	3	1
UCEC	p90 RSK_pT359_S363 →	-0.190	-2.115	.031	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

HER3_pY1289 by PCNP expression — UCEC

Explore this box plot interactively →