PCNA

Across TCGA patient cohorts, PCNA protein abundance is significantly associated with the RNA expression of many other genes, with 19,340 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PCNA-associated genes across cancer lineages are CDKN3, GINS1, and CENPI. Each is linked with PCNA in more than 9 cancer types. Because this analysis shows association rather than direction, both PCNA-to-partner and partner-to-PCNA results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCNA versus CDKN3 in LUAD, with a Pearson correlation of 0.63.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNA→partner) and Y-score (partner→PCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDKN3 →	+1.165	+0.458	<.001	<.001	3	10
LUAD	GINS1 →	+1.294	+0.533	<.001	<.001	3	10
LUAD	CENPI →	+1.185	+0.517	<.001	<.001	3	10
LUAD	NCAPG →	+1.216	+0.547	<.001	<.001	3	10
OV	KIF20A →	+1.366	+0.682	<.001	<.001	3	10
OV	CENPA →	+1.388	+0.652	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,340 associations by consensus.

PCNA vs CDKN3 — LUAD

Explore this scatter interactively →