PCNA

Across TCGA patient cohorts, PCNA mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCNA-associated genes across cancer lineages are JNK2, Ku80, and MEK1. Each is linked with PCNA in more than 1 cancer types. Because this analysis shows association rather than direction, both PCNA-to-partner and partner-to-PCNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by PCNA-low versus PCNA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCNA→partner) and Y-score (partner→PCNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.256	+3.906	.003	<.001	3	1
UCEC	Ku80 →	+0.211	+1.598	.040	.044	3	1
UCEC	MEK1 →	+0.486	+3.584	.002	.002	3	1
UCEC	PDK1_pS241 →	+0.166	+2.128	.026	.010	3	1
UCEC	PR →	-0.225	-3.169	.040	.019	3	1
UCEC	Rad50 →	-0.269	-2.807	.011	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

JNK2 by PCNA expression — UCEC

Explore this box plot interactively →