PCM1

Across TCGA patient cohorts, PCM1 mutation is significantly associated with the RNA expression of many other genes, with 4,842 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCM1-associated genes across cancer lineages are GSR, RBBP4, and TIPIN. Each is linked with PCM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCM1-to-partner and partner-to-PCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSR grouped by PCM1-low versus PCM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCM1→partner) and Y-score (partner→PCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSR →	+0.551	+2.343	<.001	<.001	3	4
UCEC	RBBP4 →	+0.350	+1.233	.002	.002	3	4
UCEC	TIPIN →	+0.567	+2.209	<.001	<.001	3	4
UCEC	PLA2G12AP1 →	+0.270	+1.151	<.001	.004	3	4
UCEC	RNU2-27P →	+0.546	+1.963	<.001	<.001	3	4
UCEC	NCAPH2 →	+0.642	+2.874	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,842 associations by consensus.

GSR by PCM1 expression — UCEC

Explore this box plot interactively →