PCM1

Across TCGA pan-cancer cohorts, PCM1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PCM1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PCM1 RNA is repressed in tumor relative to normal tissue. In most cancer types PCM1 is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

BLCA, LUSC, and KICH are the cancer types where PCM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−0.753	.008	6	view →
LUSC	Male	All	−0.547	<.001	5	view →
KICH	Female	All	−1.010	<.001	4	view →
THCA	All	All	−0.311	.003	4	view →
CHOL	All	All	+1.683	<.001	3	view →
READ	All	III,IV	+0.809	.021	2	view →
UCEC	All	All	−0.458	.020	2	view →
READ	Female	All	−0.576	.034	1	view →
KIRP	Male	All	−0.410	.007	1	view →
HNSC	Male	All	−0.353	.037	1	view →
LIHC	All	All	+0.341	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

PCM1–BLCA

Open the BLCA breakdown →