PCM1

Across TCGA cell cohorts, PCM1 mutation is significantly associated with the RNA expression of many other genes, with 1,538 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCM1-associated genes across cancer lineages are STATH, RNF212B, and KCNA1. Each is linked with PCM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PCM1-to-partner and partner-to-PCM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STATH grouped by PCM1-low versus PCM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCM1→partner) and Y-score (partner→PCM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	STATH →	+0.209	+3.133	<.001	<.001	3	3
CNS	RNF212B →	+0.252	+3.978	<.001	.005	3	3
KIDNEY	KCNA1 →	+0.006	+5.000	<.001	.005	3	2
STOMACH	TBC1D3C →	+0.661	+2.954	.001	.005	3	2
OVARY	ASB17 →	+0.011	+3.807	<.001	.009	3	2
LARGE_INTESTINE	PPM1A →	+0.445	+2.584	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,538 associations by consensus.

STATH by PCM1 expression — BLOOD_Leukemia

Explore this box plot interactively →