Across TCGA patient cohorts, PCLO RNA expression is significantly associated with the protein abundance of many other proteins, with 17,928 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCLO-associated proteins across cancer lineages are PCLO_S826, OPA1, and PTPRC_S975. Each is linked with PCLO in more than 8 cancer types. Because this analysis shows association rather than direction, both PCLO-to-partner and partner-to-PCLO results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLO→partner) and Y-score (partner→PCLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PCLO_S826 →	+1.630	+2.462	<.001	.002	3	9
LSCC	OPA1 →	+0.508	+0.960	<.001	<.001	3	5
BRCA	PTPRC_S975 →	-0.793	-0.827	<.001	<.001	3	5
UCEC	NAXE →	+0.320	+1.082	.002	<.001	3	4
HNSC	PCLO_S906 →	+1.296	+1.901	<.001	<.001	3	4
GBM	PFN1 →	-0.252	-0.812	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,928 associations by consensus.

Exploration

PCLO survival (RNA) · tumor vs normal (RNA) · all PCLO data types