Across TCGA pan-cancer cohorts, PCLO RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of PCLO’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where PCLO RNA is repressed in tumor relative to normal tissue. In most cancer types PCLO is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.
THCA, KIRC, and BLCA are the cancer types where PCLO tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCLO RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.