Across TCGA patient cohorts, PCLO protein abundance is significantly associated with the RNA expression of many other genes, with 5,476 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCLO-associated genes across cancer lineages are BBOX1, KIAA0513, and RAB30. Each is linked with PCLO in more than 1 cancer types. Because this analysis shows association rather than direction, both PCLO-to-partner and partner-to-PCLO results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLO→partner) and Y-score (partner→PCLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	BBOX1 →	+1.452	+0.591	.002	.006	3	2
GBM	KIAA0513 →	+0.965	+0.635	<.001	<.001	3	2
UCEC	RAB30 →	-0.544	-0.899	.002	.003	3	2
LSCC	ZKSCAN2 →	-0.307	-0.371	.002	.008	3	2
UCEC	PTMS →	-0.418	-0.561	.005	.009	3	2
UCEC	BRSK1 →	-0.908	-0.785	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,476 associations by consensus.

Exploration

PCLO survival (RNA) · tumor vs normal (RNA) · all PCLO data types