Across TCGA patient cohorts, PCLO mutation is significantly associated with the RNA expression of many other genes, with 11,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCLO-associated genes across cancer lineages are CEP55, KIF11, and MIS18A. Each is linked with PCLO in more than 7 cancer types. Because this analysis shows association rather than direction, both PCLO-to-partner and partner-to-PCLO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLO→partner) and Y-score (partner→PCLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	CEP55 →	+1.149	+3.459	<.001	.005	3	8
LUAD	KIF11 →	+0.527	+1.561	<.001	<.001	3	8
STAD	MIS18A →	+0.481	+1.887	<.001	<.001	3	7
LUAD	NEK2 →	+0.609	+1.232	<.001	<.001	3	7
UCEC	MND1 →	+0.593	+1.310	<.001	<.001	3	7
STAD	AUNIP →	+0.462	+3.297	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,156 associations by consensus.

Exploration

PCLO survival (RNA) · tumor vs normal (RNA) · all PCLO data types