Across TCGA cell cohorts, PCLO RNA expression is significantly associated with the go_rna of many other GO terms, with 2,766 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PCLO-associated GO terms across cancer lineages are Presynaptic active zone assembly, Negative regulation of syncytium formation by plasma membrane fusion, and Regulation of myoblast fusion. Each is linked with PCLO in more than 15 cancer types. Because this analysis shows association rather than direction, both PCLO-to-partner and partner-to-PCLO results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLO→partner) and Y-score (partner→PCLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Presynaptic active zone assembly →	+1.200	+1.576	<.001	<.001	3	16
KIDNEY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.116	+1.206	<.001	<.001	3	11
KIDNEY	Regulation of myoblast fusion →	+0.119	+1.208	<.001	<.001	3	11
BREAST	Golgi vesicle transport →	+0.058	+0.917	<.001	.008	3	10
STOMACH	Synaptic vesicle clustering →	-0.295	-1.601	<.001	<.001	3	10
KIDNEY	Vesicle-mediated transport to the plasma membrane →	+0.056	+1.471	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,766 associations by consensus.

Exploration

PCLO survival (RNA) · tumor vs normal (RNA) · all PCLO data types