Across TCGA cell cohorts, PCLO mutation is significantly associated with the RNA expression of many other genes, with 1,752 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCLO-associated genes across cancer lineages are SLC25A12, TNFRSF13C, and CCDC110. Each is linked with PCLO in more than 3 cancer types. Because this analysis shows association rather than direction, both PCLO-to-partner and partner-to-PCLO results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCLO→partner) and Y-score (partner→PCLO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC25A12 →	+0.509	+2.459	.002	.005	3	4
OVARY	TNFRSF13C →	+0.426	+2.807	.001	<.001	3	3
OVARY	CCDC110 →	+0.578	+2.115	.001	.007	3	3
OVARY	SRPRA →	-0.566	-2.807	.002	<.001	3	3
SKIN	TMCC3 →	-0.651	-1.252	.002	<.001	3	3
LARGE_INTESTINE	HDDC2 →	+0.483	+1.485	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,752 associations by consensus.

Exploration

PCLO survival (RNA) · tumor vs normal (RNA) · all PCLO data types