PCK2

Across TCGA patient cohorts, PCK2 protein abundance is significantly associated with the RNA expression of many other genes, with 11,410 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCK2-associated genes across cancer lineages are KLHL7, ZSWIM7, and DSE. Each is linked with PCK2 in more than 4 cancer types. Because this analysis shows association rather than direction, both PCK2-to-partner and partner-to-PCK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCK2 versus KLHL7 in BRCA, with a Pearson correlation of -0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK2→partner) and Y-score (partner→PCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KLHL7 →	-0.510	-0.388	<.001	<.001	3	5
OV	ZSWIM7 →	-0.457	-0.355	.001	.003	3	5
BRCA	DSE →	-0.667	-0.409	<.001	<.001	3	5
LSCC	KDM5B →	-0.759	-0.346	<.001	<.001	3	5
LSCC	POGLUT2 →	-0.560	-0.379	.002	.001	3	5
LSCC	RCN2 →	-0.591	-0.307	.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,410 associations by consensus.

PCK2 vs KLHL7 — BRCA

Explore this scatter interactively →