PCK2

Across TCGA patient cohorts, PCK2 mutation is significantly associated with the RNA expression of many other genes, with 1,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCK2-associated genes across cancer lineages are RNA5SP73, LINC02434, and ACTBP7. Each is linked with PCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCK2-to-partner and partner-to-PCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP73 grouped by PCK2-low versus PCK2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK2→partner) and Y-score (partner→PCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP73 →	+0.125	+4.121	.001	.009	3	2
SKCM	LINC02434 →	+1.367	+3.713	.006	.004	3	2
UCEC	ACTBP7 →	+0.394	+2.225	.001	.001	3	2
UCEC	DEFB122 →	+0.091	+1.907	.001	.003	3	2
UCEC	TRAJ21 →	+0.318	+1.911	.006	.005	3	2
UCEC	TRAJ11 →	+0.344	+1.643	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,573 associations by consensus.

RNA5SP73 by PCK2 expression — BRCA

Explore this box plot interactively →