PCK2

Across TCGA cell cohorts, PCK2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCK2-associated genes across cancer lineages are CACNG2, AVP, and MROH2B. Each is linked with PCK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCK2-to-partner and partner-to-PCK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CACNG2 grouped by PCK2-low versus PCK2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCK2→partner) and Y-score (partner→PCK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CACNG2 →	+0.557	+4.011	<.001	.009	3	2
LARGE_INTESTINE	AVP →	+0.054	+4.047	<.001	<.001	3	2
BLOOD_Lymphoma	MROH2B →	+0.069	+4.058	<.001	.009	3	2
PANCREAS	PRKACG →	+0.005	+4.614	<.001	.004	3	1
PANCREAS	OR4N2 →	+0.010	+4.614	<.001	.004	3	1
PANCREAS	UBTFL1 →	+0.015	+4.614	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

CACNG2 by PCK2 expression — PANCREAS

Explore this box plot interactively →