PCIF1

Across TCGA patient cohorts, PCIF1 mutation is significantly associated with the RNA expression of many other genes, with 2,031 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCIF1-associated genes across cancer lineages are RNA5SP412, RNA5SP413, and HMGB1P17. Each is linked with PCIF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCIF1-to-partner and partner-to-PCIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by PCIF1-low versus PCIF1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCIF1→partner) and Y-score (partner→PCIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP412 →	+0.754	+4.993	<.001	.003	3	4
LUSC	RNA5SP413 →	+1.871	+4.496	<.001	.007	3	3
COAD	HMGB1P17 →	+0.226	+3.474	.001	<.001	3	2
LUSC	TRBV24OR9-2 →	+0.392	+4.297	<.001	.009	3	2
LUSC	RNU6-1267P →	+0.669	+3.920	<.001	.007	3	2
LUSC	PABPC1L2B-AS1 →	+0.023	+4.853	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,031 associations by consensus.

RNA5SP412 by PCIF1 expression — LUSC

Explore this box plot interactively →