PCID2

Across TCGA cell cohorts, PCID2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,164 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PCID2-associated GO terms across cancer lineages are Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery, Ribosomal protein import into nucleus, and Nucleotide-excision repair, DNA gap filling. Each is linked with PCID2 in more than 18 cancer types. Because this analysis shows association rather than direction, both PCID2-to-partner and partner-to-PCID2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery grouped by PCID2-low versus PCID2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCID2→partner) and Y-score (partner→PCID2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.134	+1.097	.003	.002	3	19
BREAST	Ribosomal protein import into nucleus →	+0.121	+0.762	<.001	<.001	3	19
PANCREAS	Nucleotide-excision repair, DNA gap filling →	+0.109	+0.769	<.001	.001	3	13
LUNG_SCLC	Attachment of mitotic spindle microtubules to kinetochore →	+0.128	+0.954	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome →	+0.089	+0.945	.001	<.001	3	11
LUNG_SCLC	Centrosome duplication →	+0.100	+0.858	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,164 associations by consensus.

Post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery by PCID2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →