PCID2

Across TCGA pan-cancer cohorts, PCID2 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PCID2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PCID2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCID2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where PCID2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCID2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.360	<.001	11	view →
THCA	Male	IV	−0.533	<.001	10	view →
KICH	Female	II,III,IV	−1.505	<.001	9	view →
LIHC	All	II,III,IV	+0.752	<.001	8	view →
HNSC	All	All	+0.564	<.001	8	view →
READ	All	II,III,IV	+1.100	<.001	7	view →
CHOL	All	All	+1.492	<.001	5	view →
BLCA	All	All	+0.301	.004	5	view →
STAD	All	II,III,IV	+0.605	<.001	4	view →
LUSC	All	All	+0.510	.003	2	view →
UCEC	All	All	−0.364	.028	2	view →
LUAD	Male	All	+0.243	.011	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PCID2–COAD

Open the COAD breakdown →