PCGF6

Across TCGA cell cohorts, PCGF6 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PCGF6-associated genes across cancer lineages are PLPPR1, MTNR1A, and SFTPB. Each is linked with PCGF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF6-to-partner and partner-to-PCGF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLPPR1 grouped by PCGF6-low versus PCGF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF6→partner) and Y-score (partner→PCGF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLPPR1 →	+0.351	+3.389	.004	.007	3	1
LARGE_INTESTINE	MTNR1A →	+0.573	+3.064	<.001	.009	3	1
LARGE_INTESTINE	SFTPB →	+0.170	+3.770	<.001	.001	3	1
LARGE_INTESTINE	ZBTB21 →	+0.649	+3.064	.001	.009	3	1
LARGE_INTESTINE	C5orf60 →	+0.110	+3.125	<.001	.008	3	1
LARGE_INTESTINE	TUBB8 →	+0.396	+3.184	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

PLPPR1 by PCGF6 expression — LARGE_INTESTINE

Explore this box plot interactively →