PCGF1

Across TCGA patient cohorts, PCGF1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCGF1-associated genes across cancer lineages are Rab25, eIF4E, and MEK1. Each is linked with PCGF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PCGF1-to-partner and partner-to-PCGF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab25 grouped by PCGF1-low versus PCGF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCGF1→partner) and Y-score (partner→PCGF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.376	-3.169	.039	.019	3	1
UCEC	eIF4E →	+0.255	+3.169	.027	.020	1	2
UCEC	MEK1 →	+0.534	+3.000	.007	.036	2	1
UCEC	BRCA2 →	-0.227	-2.992	.001	.036	2	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.950	+3.169	<.001	.020	1	1
UCEC	Cyclin-B1 →	+0.661	+3.169	.032	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Rab25 by PCGF1 expression — UCEC

Explore this box plot interactively →