PCF11

Across TCGA patient cohorts, PCF11 protein abundance is significantly associated with the RNA expression of many other genes, with 14,609 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PCF11-associated genes across cancer lineages are DDIAS, XPO5, and USP21. Each is linked with PCF11 in more than 6 cancer types. Because this analysis shows association rather than direction, both PCF11-to-partner and partner-to-PCF11 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PCF11 versus DDIAS in HNSC, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCF11→partner) and Y-score (partner→PCF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDIAS →	+1.099	+0.281	<.001	<.001	3	7
LSCC	XPO5 →	+0.510	+0.179	<.001	<.001	3	6
UCEC	USP21 →	+0.607	+0.194	<.001	.001	3	6
GBM	CHTOP →	+0.394	+0.297	<.001	<.001	3	6
UCEC	UBQLN4 →	+0.650	+0.165	<.001	<.001	3	6
UCEC	CLK2 →	+0.524	+0.157	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,609 associations by consensus.

PCF11 vs DDIAS — HNSC

Explore this scatter interactively →