PCF11

Across TCGA patient cohorts, PCF11 mutation is significantly associated with the RNA expression of many other genes, with 6,277 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCF11-associated genes across cancer lineages are CCL3, HNRNPF, and MCM10. Each is linked with PCF11 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCF11-to-partner and partner-to-PCF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL3 grouped by PCF11-low versus PCF11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCF11→partner) and Y-score (partner→PCF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CCL3 →	+0.874	+3.013	.004	<.001	3	4
SKCM	HNRNPF →	+0.523	+3.334	.004	.005	3	4
UCEC	MCM10 →	+0.727	+1.784	<.001	<.001	3	4
COAD	RRP36 →	+0.289	+2.741	.005	.002	3	4
BRCA	STAU2P1 →	+0.134	+3.203	<.001	.006	3	3
LUAD	KIF22 →	+0.517	+3.357	.009	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,277 associations by consensus.

CCL3 by PCF11 expression — COAD

Explore this box plot interactively →