PCF11

Across TCGA patient cohorts, PCF11 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCF11-associated genes across cancer lineages are cIAP, MEK1, and PDCD4. Each is linked with PCF11 in more than 3 cancer types. Because this analysis shows association rather than direction, both PCF11-to-partner and partner-to-PCF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by PCF11-low versus PCF11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCF11→partner) and Y-score (partner→PCF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.087	+1.500	.039	.003	3	4
UCEC	MEK1 →	+0.369	+1.947	<.001	<.001	3	3
UCEC	PDCD4 →	-0.502	-2.502	<.001	.001	3	3
UCEC	ASNS →	+0.521	+2.247	<.001	.001	3	3
UCEC	c-Kit →	-0.152	-1.263	.033	.019	3	3
UCEC	4E-BP1 →	+0.386	+1.947	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

cIAP by PCF11 expression — UCEC

Explore this box plot interactively →