PCF11

Across TCGA cell cohorts, PCF11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,387 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PCF11-associated GO terms across cancer lineages are Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, and Protein localization to cytoplasmic stress granule. Each is linked with PCF11 in more than 18 cancer types. Because this analysis shows association rather than direction, both PCF11-to-partner and partner-to-PCF11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway grouped by PCF11-low versus PCF11-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PCF11→partner) and Y-score (partner→PCF11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.183	+1.481	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.159	+1.529	<.001	<.001	3	19
OESOPHAGUS	Protein localization to cytoplasmic stress granule →	+0.155	+1.161	.003	.004	3	15
UPPER_AERODIGESTIVE_TRACT	Protein polyubiquitination →	+0.047	+1.082	.008	.004	3	14
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.097	+0.583	<.001	.002	2	15
UPPER_AERODIGESTIVE_TRACT	Regulation of mRNA processing →	+0.080	+0.962	<.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,387 associations by consensus.

Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway by PCF11 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →