PCED1A

Across TCGA patient cohorts, PCED1A mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCED1A-associated genes across cancer lineages are PCNA, EGFR_pY1068, and eIF4E. Each is linked with PCED1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PCED1A-to-partner and partner-to-PCED1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PCED1A-low versus PCED1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCED1A→partner) and Y-score (partner→PCED1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.263	+3.087	.002	<.001	3	2
UCEC	EGFR_pY1068 →	-0.271	-3.087	.007	<.001	3	1
UCEC	eIF4E →	+0.221	+3.459	.009	.005	3	1
UCEC	FASN →	+0.344	+1.906	.030	.016	3	1
UCEC	FOXO3a_pS318_S321 →	-0.110	-2.105	.028	.017	3	1
UCEC	IGFBP2 →	-0.682	-2.321	.009	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

PCNA by PCED1A expression — UCEC

Explore this box plot interactively →